The clinical trial is one of the first CAR T trials for prostate cancer in the nation and can enroll up to 33 patients. About Mustang Bio Mustang Bio, Inc. is a clinical-stage biopharmaceutical company focused on translating today’s medical breakthroughs in cell and gene therapies into potential cures for hematologic cancers, solid tumors and rare genetic diseases. Mustang was founded by Fortress Biotech, Inc. (NASDAQ: FBIO). About MB-102 (CD123-targeted CAR T Cell Therapy)MB-102 is a CAR T cell therapy that is produced by engineering patient T cells to recognize and eliminate CD123-expressing tumors. Our hope is that this CAR T cell therapy can be a game changer for these patients.”. Forward‐Looking StatementsThis press release may contain “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, each as amended. October 30, 2017 GENETIC AND ENGINEERING NEWS: Mustang Bio Plans Manufacturing Facility in Worcester, MA. Small Chart; Medium Chart; Large Chart At Mustang Bio we are driven by people. The median survival for men with CRPC is less than two years, according to the American Urological Association. Dose escalation continues at City of Hope in both indications. MB-102 has received Orphan Drug Designations from the U.S. Food and Drug Administration for AML and BPDCN. The primary outcome that will be studied is the response rate at day 28 post infusion in all arms. Fax: (973) 299-7937. Factors that could cause actual results to differ materially from those currently anticipated include: risks relating to our growth strategy; our ability to obtain, perform under, and maintain financing and strategic agreements and relationships; risks relating to the results of research and development activities; risks relating to the timing of starting and completing clinical trials; uncertainties relating to preclinical and clinical testing; our dependence on third-party suppliers; our ability to attract, integrate and retain key personnel; the early stage of products under development; our need for substantial additional funds; government regulation; patent and intellectual property matters; competition; as well as other risks described in our SEC filings. April 20-22, 2021, New York, NY, DRUG DEVELOPMENT & DELIVERY Forward-looking statements are based on management’s current expectations and are subject to risks and uncertainties that could negatively affect our business, operating results, financial condition and stock value. Forward-looking statements are based on management’s current expectations and are subject to risks and uncertainties that could negatively affect our business, operating results, financial condition and stock value. Web design and development by WalkerTek. Manuel Litchman, M.D., President and Chief Executive Officer of Mustang, said, “This is a momentous occasion for Mustang, as it is the first clinical trial under Mustang’s investigational new drug application (IND) in which a patient was dosed with cells processed in our own manufacturing facility. The Prostate Cancer Foundation provided support for the preclinical research efforts that led to the trial’s development, as well as support for the clinical trial. In 2019, there were about 174,650 new cases of prostate cancer in the US, and roughly one out of every nine men will be diagnosed with prostate cancer during his lifetime. Mustang has partnered with top medical institutions to advance the development of CAR T and CRISPR/Cas9-enhanced CAR T therapies across multiple cancers, as well as a lentiviral gene therapy for XSCID. Mustang was founded by Fortress Biotech, Inc.. For more information, visit www.mustangbio.com. Mustang Bio, Inc. recently announced that City of Hope, a world-renowned independent cancer research and treatment center, has opened and is beginning to treat its first patients in a Phase 1 clinical trial of MB-105, a prostate stem cell antigen (PSCA) chimeric antigen receptor (CAR) T technology, for the treatment of prostate cancer. We look forward to advancing the development of MB-102 and providing updates on the trial as we seek to help address the needs of patients suffering from the devastating diseases of BPDCN, AML and hrMDS.”. Overview; Stock Information; Press Releases; SEC Filings; Events; Management Team; Board of Directors; Corporate Presentation; Corporate Governance; FAQs; Information Request; Email Notification; Careers. Such statements include, but are not limited to, any statements relating to our growth strategy and product development programs and any other statements that are not historical facts. According to the American Cancer Society, prostate cancer is the most common cancer in American men, excluding skin cancer. Its primary endpoints are to define the side effects and best dose of PSCA CAR T cells in treating patients with PSCA-positive castration-resistant prostate cancer (CRPC) that has metastasized to other areas in the body. For more information, visit www.mustangbio.com. Mustang Bio, Inc. (“Mustang”) is a clinical-stage biopharmaceutical company focused on translating today’s medical breakthroughs in cell and gene therapies into potential cures for hematologic cancers, solid tumors and rare genetic diseases. Mustang Bio, Inc. recently announced that City of Hope, a world-renowned independent cancer research and treatment center, has opened and is beginning to treat its first patients in a Phase 1 clinical trial of MB-105, a prostate stem cell antigen (PSCA) chimeric antigen receptor (CAR) T technology, for the treatment of prostate cancer. Clinical Trials; Partnering . Fortress Biotech programs include product candidates in development at Fortress, its majority-owned and majority-controlled partner companies and entities in which it holds minority ownership positions. In the first-in-human clinical trial at City of Hope (NCT02159495), MB-102 has demonstrated complete responses at low doses in AML and BPDCN without dose-limiting toxicities, as reported at the American Society of Hematology (ASH) Annual Meeting in December 2017 and the American Association for Cancer Research (AACR) Special Conference on Tumor Immunology and Immunotherapy in November 2018.
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