But it turns out there may be a drug that does qualify as a “miracle COVID-19 cure,” one that might save plenty of severe COVID-19 patients. The company said 83 per cent of ventilator-dependent patients with a high risk of mortality who received its stem cell treatment have survived during early compassionate usage in New York's Mount Sinai hospital. The promising therapy uses “medicinal signaling cells” or MSCs, which are found on blood vessels throughout the body, explained Kevin Kimberlin in a Wall Street Journal op-ed. It says a lot about the depth and breadth of the coronavirus disaster in the US that the FDA was willing to move so quickly to approve the use of the Mesoblast treatment on US patients. Years of work in stem cell therapy technology by Mesoblast could soon be used to help COVID-19 patients in the United States facing the final and worst phase of the virus. There may be a conflict of interest present with commercial arrangements with companies and/or stock held. “If the cells work in COVID-19 ARDS, we’re in a position to provide products to as many patients as possible.”. Listed biotech company Mesoblast says it is seeing positive signs for the use of its stem cell therapy in treating critically ill COVID-19 patients. According to the CDC, between 20-42% of hospitalized COVID-19 patients develop ARDS, with as many as 85% of patients admitted to intensive care having this complication. “We hope that what we’re doing is complementary to what folks who are developing vaccines and antivirals are doing.”, Full coverage and live updates on the Coronavirus. Mesoblast said three-quarters of the patients successfully came off ventilator support within a median 10 days, compared with only 9 per cent of ventilator-dependent COVID-19 patients with standard of care treatment. Moreover, Covid-19 patients who developed severe ARDS were more likely to be elderly and have co-existing conditions like diabetes and chronic kidney disease. But in an MSCs trial, 160 of 239 patients who did not respond to steroids survived after infusions with MSCs. It possesses immunomodulatory properties that are believed to counteract the inflammatory properties found in several diseases. Plenty of promising therapies are in clinical trials right alongside vaccines, as the world will need therapeutics that can cure the infection as well as drugs that can prevent it. Josh Robenstone. The randomized, double-blinded, controlled trial will evaluate Mesoblast's mesenchymal stem cell product, remestemcel-L, plus maximal care in ARDS, the main cause of death in patients with COVID-19. Small Caps and affiliated companies accept no responsibility for any claim, loss or damage as a result of information provided or its accuracy. A health stock that’s undertaking a U.S. coronavirus drug trial and has seen its market value more than triple since March will be added to Australia’s benchmark equity gauge next week. As such, Mesoblast has made the logical connection that the drug is likely to have a similar effect on patients with ARDS caused by Covid-19 given the similarities between the conditions. Whenever he's not writing about gadgets he miserably fails to stay away from them, although he desperately tries. Stem cell specialist Mesoblast (MSB) is joining the race to treat Covid-19 coronavirus patients The company will test its remestemcel-L product on Covid-19 patients who develop acute respiratory distress syndrome (ARDS) According to Mesoblast, this condition is the principal cause of death in Covid-19 According to Mesoblast, the mortality rate for Covid-19 patients with ARDS is upwards of 50 per cent. Jackie Edwards, June 18, 2020, 3:00 PM EDT ... Mesoblast has also bolstered … The product candidate was being reviewed by the FDA for potential approval in the treatment of children with steroid-refractory aGVHD. Mesoblast said in a recent clinical study which tested MSCs in seven patients with severe Covid-19 pneumonia, the treatment either completely cured or significantly improved functional outcomes for all patients. VIX leaps. The Remestemcel-L is administered to patients via a series of intravenous infusions. Help using this website - Accessibility statement. This compassionate use treatment experience will now help Mesoblast in the creation of its randomised, placebo-controlled Phase 2/3 trial in COVID-19 ARDS patients as it seeks to confirm that its remestemcel-L improves survival in these critically ill patients across North America.
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